Rams vs 49ers Thursday Night Football: Channel, Start Time & Live Streaming
The Los Angeles Rams and the San Francisco 49ers are set to clash on Thursday Night Football. Few rivalries in the NFL carry the same intensity. Both teams want to control the NFC West early in the season. Because of that, fans expect an explosive game with plenty of drama under the lights.
NFL viewers across the United States often ask three questions: what channel shows the game, when does it start, and how can they stream it live? This week’s Rams vs 49ers Thursday Night Football matchup will stream exclusively on Amazon Prime Video. Unlike Sunday or Monday games, Thursday belongs to Prime. Fans will need an active subscription to watch every snap. The app is available on smart TVs, mobile devices, and streaming sticks, so tuning in is simple and fast.
Beyond broadcast details, the game itself matters a great deal. The Rams want Matthew Stafford and Cooper Kupp to ignite their offense. The 49ers rely on their dominant defense and big-play stars like Christian McCaffrey. Add decades of heated rivalry, and you get one of the most anticipated games of the year. In this complete guide, you’ll discover everything about Rams vs 49ers Thursday Night Football—from kickoff time and live channels to streaming options, schedule breakdowns, predictions, and betting insights.
Rams vs 49ers: Date, Time & Venue
The Rams will visit the 49ers on Thursday, October 2, 2025. Kickoff is scheduled for 8:15 PM ET (5:15 PM PT). The game takes place at Levi’s Stadium in Santa Clara, California. Known for its loud crowds and playoff history, Levi’s will once again host one of the NFL’s biggest rivalries.
What Channel Is Rams vs 49ers On?
The Rams vs 49ers Thursday Night Football game airs exclusively on Amazon Prime Video. Fans cannot watch this matchup on traditional networks like NBC, ESPN, or FOX. Amazon’s streaming deal gives it full rights to every Thursday night game through the NFL season.
To watch, you need a Prime subscription. Once subscribed, simply open the Prime Video app or visit the website. With streaming available on nearly all devices, including Roku, Fire Stick, Apple TV, and gaming consoles, access is straightforward for fans across the U.S.
How to Stream Rams vs 49ers Live Online
Streaming options give fans flexibility. Here are the best ways to watch:
- Amazon Prime Video: The exclusive home of TNF in 2025.
- Smart TVs: Samsung, LG, and Sony models support Prime Video apps.
- Mobile Devices: Download Prime Video on iOS or Android.
- Streaming Devices: Roku, Fire Stick, Apple TV, PlayStation, and Xbox all support Prime.
- Free Trial: New Prime members can often use a free trial to stream games.
Because of these options, nearly every NFL fan in the U.S. has a way to watch Rams vs 49ers live.
Full NFL Week 5 Schedule
The Rams vs 49ers Thursday Night Football game kicks off Week 5. Below is the full lineup:
- Thursday: Rams vs 49ers – 8:15 PM ET (Prime Video)
- Sunday Early Games: Eagles vs Cowboys, Dolphins vs Jets, Steelers vs Bengals
- Sunday Afternoon: Chiefs vs Chargers, Seahawks vs Cardinals
- Sunday Night Football: Bills vs Patriots – 8:20 PM ET (NBC)
- Monday Night Football: Packers vs Bears – 8:15 PM ET (ESPN/ABC)
Team News and Key Players
The Rams enter this matchup focused on quarterback Matthew Stafford and star receiver Cooper Kupp. Their connection remains the heart of Los Angeles’ passing attack. In addition, rookie playmakers could provide fresh energy.
The 49ers feature one of the league’s most complete rosters. Christian McCaffrey leads the offense, while Nick Bosa anchors a defense that ranks among the NFL’s best. Because of this balance, San Francisco continues to be a Super Bowl favorite.
Rams vs 49ers: Rivalry History
This NFC West rivalry stretches back decades. The 49ers have dominated recent meetings, winning nine of the last ten. However, the Rams upset San Francisco in the 2022 NFC Championship, proving they can still win big games. Every encounter feels personal, and Thursday night should be no different.
| Season | Matchup | Result |
|---|---|---|
| 2024 | Rams vs 49ers (Week 8) | 49ers 27 – Rams 17 |
| 2023 | 49ers vs Rams (Week 4) | 49ers 31 – Rams 14 |
| 2022 NFC Championship | Rams vs 49ers | Rams 20 – 49ers 17 |
Betting Odds and Predictions
Oddsmakers list the 49ers as slight favorites for this matchup. Their defense ranks top three in the league, and home-field advantage strengthens their position. However, the Rams’ offense can surprise any team when Stafford finds his rhythm.
Many analysts predict a tight contest decided late in the fourth quarter. Expect a one-score game and potentially a dramatic finish.
How to Watch Outside the U.S.
International fans can still stream Rams vs 49ers Thursday Night Football. Prime Video offers TNF games in select regions outside the U.S. For countries without access, a reliable VPN service allows fans to connect through a U.S. server and stream the game on Prime Video. Because of this, NFL fans worldwide never have to miss the action.
Why Rams vs 49ers Thursday Night Football Matters
Divisional games always carry extra weight. The NFC West remains one of the toughest divisions in football. A win here gives momentum and tie-breaker advantages. The Rams want to prove they still belong among contenders. The 49ers want to cement their status as Super Bowl favorites. For fans, this game is more than just Thursday night entertainment—it’s a potential playoff preview.
Final Thoughts
The Rams vs 49ers Thursday Night Football game offers everything fans love about the NFL: rivalry, star players, playoff stakes, and prime-time energy. With exclusive coverage on Amazon Prime Video, tuning in has never been easier. Don’t miss a single play, because this NFC West battle could shape the 2025 season.